Methotrexate Toxicity: Molecular Mechanisms and Management
نویسندگان
چکیده
Methotrexate (MTX) is the most widely used drug in cancer chemotherapy and considered to be first-line for treatment of a number rheumatic non-rheumatic disorders. The pulmonary toxicity, hepatotoxicity MTX are two its major side effects. Other toxicities such as endocrinological GI cutaneous hematological fatal malfunction or loss, malignancy can also occur, but at significantly lower rate prevalence. This review aims provide comprehensive understanding molecular mechanisms methotrexate toxic effects Lastly, we discussed management this toxicity.
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ژورنال
عنوان ژورنال: Journal of pharmaceutical research international
سال: 2021
ISSN: ['2456-9119']
DOI: https://doi.org/10.9734/jpri/2021/v33i49b33357